Eukaryotic Initiation Factor (eIF)

カタログ番号	製品名	別名	ターゲット
T11375	GCN2iB		Others , Autophagy
	GCN2iB is an ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2), with an IC50 of 2.4 nM.		Others , Autophagy
T1742	4E1rcat		PERK , Autophagy
	4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.		PERK , Autophagy
T14044	4E2RCat		PERK
			PERK
T11374	GCN2-IN-6		Others , PERK
			Others , PERK
T2665	4EGI-1	4EGI 1	Apoptosis , PERK , Autophagy
	4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).		Apoptosis , PERK , Autophagy
T3207	Briciclib	ON 014185	CDK , PERK , Autophagy
	Briciclib (ON 014185) is a small molecule that suppresses cyclin D1 accumulation in Y cells.		CDK , PERK , Autophagy
T11373	GCN2-IN-1	A-92	Others
	GCN2-IN-1 (A-92) is an effective GCN2 inhibitor and can be used in research on the treatment of cancer as a chemotherapeutic agent.		Others
T9149	2BAct	2B-Act,2B Act	PERK
	2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response		PERK
T5173	SBI-0640756	SBI 0640756,SBI-756	PERK , Autophagy
	SBI-0640756 (SBI-756) (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.		PERK , Autophagy
TP2247	eukaryotic translation initiation factor 3		Others
	Eukaryotic initiation factors (eIF) are proteins involved in the initiation phase of eukaryotic translation. Eukaryotic translation initiation factor 3 binds to the ribosome subunit-mRNA complex. It has been implicated i...		Others

Compounds

GCN2iB

T11375

Synonym:

Target: Others, Autophagy

4E1rcat

T1742

Synonym:

Target: PERK, Autophagy

Target: Apoptosis, PERK, Autophagy

Briciclib

T3207

Synonym: ON 014185

Target: CDK, PERK, Autophagy

Synonym: 2B-Act,2B Act

Target: PERK

SBI-0640756

T5173

Synonym: SBI 0640756,SBI-756

Target: PERK, Autophagy

eukaryotic translation initiation factor 3

TP2247

Synonym:

Target: Others

カタログ番号	製品名	別名	ターゲット
TQ0131	Rocaglamide	Rocaglamide A,Roc-A	HSP , NF-κB , PERK
	Rocaglamide (Roc-A), isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB activation in T-cells.

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-03184	EIF5 Protein, Human, Recombinant (GST)	Human	E. coli
	EIF5 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 44.1 kDa and the accession number is P55010.
TMPY-03795	EIF5A2 Protein, Human, Recombinant (His)	Human	E. coli
	Eukaryotic translation initiation factor 5A2 (EIF5A2) has been demonstrated to be upregulated in numerous types of human cancer and is associated with cancer progression. Silencing of EIF5A2 in the NSCLC cells resulted i...
TMPY-04108	EIF5A Protein, Human, Recombinant (His)	Human	E. coli
	EIF5A Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 18.9 kDa and the accession number is P63241-1.
TMPJ-00973	EIF1AX Protein, Human, Recombinant (His)	Human	E. coli
	Eukaryotic Translation Initiation Factor 1A, X-Chromosomal (EIF1AX) is an essential eukaryotic translation initiation factor that belongs to the eIF-1A family. EIF1AX is required for the binding of the 43S complex (a 40S...
TMPJ-00507	EIF4E Protein, Human, Recombinant	Human	E. coli
	Eukaryotic translation initiation factor 4E is a 217 amino acids protein that belongs to the eukaryotic initiation factor 4E family. eIF4F is a multi-subunit complex, the composition of which varies with external and int...
TMPH-01306	EIF4A1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary str...
TMPH-01312	EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc)	Human	E. coli
	Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F c...
TMPH-03289	EIF3I Protein, Rat, Recombinant (E. coli, His)	Rat	E. coli
	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates ...
TMPH-03288	EIF3I Protein, Rat, Recombinant (His)	Rat	Baculovirus Insect Cells
	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates ...
TMPH-01309	EIF3F Protein, Human, Recombinant (His)	Human	E. coli
	EIF3F Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 43.5 kDa and the accession number is O00303.
TMPH-01313	EIF4G1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F c...
TMPH-01307	EIF4A2 Protein, Human, Recombinant (GST)	Human	E. coli
	EIF4A2 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 73.4 kDa and the accession number is Q14240.
TMPH-01310	EIF3G Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	EIF3G Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 51.5 kDa and the accession number is O75821.
TMPY-03343	EIF3K Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	EIF3K is a member of the eIF3 subunit K family. It is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-...